Frank Caliendo, infused with a sense of comedy in his veins, started his career as a stand-up comedian, emceeing at local clubs. He later moved onto doing funny spiels on late-talk shows including Late Show with David Letterman, Late Night with Conan O'Brien. His impersonations, particularly his popular "John Madden" act, have had his audiences howling with laughter. He has appeared in TV comedy specials such as Comedy Central Presents and radio shows such as Mike & Mike in The Morning.